Marker of Ewing neoplasm Potential new drug target?

Now, Katia Scotlandi and colleagues, at SSN Emilia Romagna Istituto Ortopedico Rizzoli IRCCS, Bologna, Italy, have identified a consequential purpose for CD99 in the growth of EWS and indicate that targeting CD99 or the downstream molecular pathway competence be a new healing proceed for EWS.

In the study, dwindling CD99 countenance in human EWS cell lines marked down their capability to form tumors xenografted in to mice. In vitro, it increasing countenance of H-neurofilament, a pen of neuronal differentiation. Consistent with this, an different association in between CD99 countenance and H-neurofilament expression, neural differentiation, and oncogenic mutation was noticed in patient-derived EWS cells.

The authors thus interpretation that CD99 prevents neural split and indicate that restraint it competence yield a new proceed to treating EWS.

The investigate appears in the Journal of Clinical Investigation.

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